Terkini! Faktor genetik mempengaruhi 8 ciri kuantitatif penduduk di Asia

Baru-baru ini hasil daripada penyelidikan dalam bidang genetik manusia mendapati bahawa faktor genetik mempengaruhi 8 ciri kuantitatif genetik bagi penduduk Asia (khasnya di Korea).

Lapan ciri warisan tersebut ialah ketinggian, indeks berat badan, kadar denyutan jantung, tekanan darah sistolik, nisbah pinggang: punggung, densiti mineral tulang pada tibia (betis) dan tumit.

Maklumat selanjutnya boleh didapati dalam artikel di Jurnal Nature Genetics (2009)….

Nature Genetics 41, 527 – 534 (2009)
Published online: 26 April 2009 | doi:10.1038/ng.357

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

Yoon et al. (2009)


To identify genetic factors influencing quantitative traits of biomedical importance, we conducted a genome-wide association study in 8,842 samples from population-based cohorts recruited in Korea. For height and body mass index, most variants detected overlapped those reported in European samples. For the other traits examined, replication of promising GWAS signals in 7,861 independent Korean samples identified six previously unknown loci. For pulse rate, signals reaching genome-wide significance mapped to chromosomes 1q32 (rs12731740, P = 2.9 times 10-9) and 6q22 (rs12110693, P = 1.6 times 10-9), with the latter approx400 kb from the coding sequence of GJA1. For systolic blood pressure, the most compelling association involved chromosome 12q21 and variants near the ATP2B1 gene (rs17249754, P = 1.3 times 10-7). For waist-hip ratio, variants on chromosome 12q24 (rs2074356, P = 7.8 times 10-12) showed convincing associations, although no regional transcript has strong biological candidacy. Finally, we identified two loci influencing bone mineral density at multiple sites.

On chromosome 7q31, rs7776725 (within the FAM3C gene) was associated with bone density at the radius (P = 1.0 times 10-11), tibia (P = 1.6 times 10-6) and heel (P = 1.9 times 10-10). On chromosome 7p14, rs1721400 (mapping close to SFRP4, a frizzled protein gene) showed consistent associations at the same three sites (P = 2.2 times 10-3, P = 1.4 times 10-7 and P = 6.0 times 10-4, respectively).

This large-scale GWA analysis of well-characterized Korean population-based samples highlights previously unknown biological pathways.


Tidak ada gunanya …..kalau…

Orang berbahagia itu selalu menyedari bahawa tidak ada faedahnya:

1. perkataan kalau tidak disertai dengan perbuatan,
2. tidak ada gunanya kepintaran kalau tidak disertai dengan budi,
3. tidak ada gunanya derma kalau tidak disertai dengan niat suci,
4. tidak ada gunanya kejujuran kalau tidak sanggup memegang janji,
5. tidak ada gunanya hidup kalau tidak disertai kesihatan, dan
6. tidak ada gunanya negeri yang makmur kalau hati penduduknya penuh kekecewaan.
~ Hukamah

Rawatan di rumah: Gout

Apakah Rawatan di Rumah?

Rawatan di rumah (home remedies) ialah perubatan secara tradisional atau semulajadi yang telah diamalkan sejak turun-temurun dan oleh beberapa generasi, tanpa perlu risau dengan kesan sampingannya. Selalunya rawatan di rumah ini berkait rapat dengan bahan-bahan yang digunakan hari-hari di dapur.

Gout adalah salah satu daripada arthritis yang sangat sakit. Selain daripada ubat yang dicadangkan oleh doktor, pesakit gout juga boleh mencuba rawatan di rumah secara semulajadi dengan menggunakan bahan di dapur yang mudah diperolehi dan digunakan hari-hari.

Artikel berikut memperincikan cara rawatan di rumah untuk gout…. selamat mencuba kepada pesakit gout.

Gout Home Remedies

The most painful form of arthritis is gout. This is caused by too much uric acid build up in the body and usually felt in the big toe. The accumulation of uric acid in the body looks like lumps in the skin. The pain can be accompanied by swelling, redness and stiffness in joints. The people who are prone to have gout are those who have a strong family history of gout, take too much alcohol or eating foods with purines excessively. They also occur mostly in men or if the person is overweight.

Gout is identified by doctors by these symptoms:

– Hyperuricemia (high level of uric acid in the blood)
– Uric acid crystals in joint fluid
– More than attack of uric arthritis
– Arthritis that develops in 1 day, producing a swollen, red and warm joint.
– Attack of arthritis in only 1 joint, usually the toe, ankle or knee.

It is believed that the old fashioned way of treating gout is now useless and ineffective.
But these tips of gout home remedies are effective and are sure to sooth gout pain in no time.

Drink a lot of water – with the help of water, this will eliminate all the uric acid build up in your system. It does not only cleanse the unwanted acids but also flush out unwanted toxins.

Garlic – adding garlic as a garnish or eating garlic serves as one of gout home remedies since it restrains the production of uric acid.

Wheat grass and Chlorella – it is said that it helps lower down the alkalinity of your body.

Drinking cherry juice or eating cherry fruit – cherry has magnesium and vitamin c that supports in the digestion and circulation of our body. Thus, helping people to lower down the uric acid level.

Thyme – it is not only used to add aroma and extra flavour to our dishes but it counts as one of gout home remedies. Use it as a tea and enjoy its anti-inflammatory
components to facilitate lesser uric acid production.

Aside from doing these simple gout home remedies, you can actually prevent gout to happen.

First, know the importance of exercise. It keeps your systems on the run and at the same time, it nourishes the joint cartilage.

Second is to increase your vegetable and fruit intake. Green, leafy vegetables and fruits such as berries, citrus fruits and tomatoes are rich in vitamin C and bioflavonoid to reduce uric acid levels.

Lastly, target 8-10 glasses of water per day to help dilute uric acid.


Today’s Quote – 25

For everything you have missed, you have gained something else; And for everything you gain, you lose something else. It is about your outlook towards life. You can either regret or rejoice.

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