Terkini! Faktor genetik mempengaruhi 8 ciri kuantitatif penduduk di Asia

Baru-baru ini hasil daripada penyelidikan dalam bidang genetik manusia mendapati bahawa faktor genetik mempengaruhi 8 ciri kuantitatif genetik bagi penduduk Asia (khasnya di Korea).

Lapan ciri warisan tersebut ialah ketinggian, indeks berat badan, kadar denyutan jantung, tekanan darah sistolik, nisbah pinggang: punggung, densiti mineral tulang pada tibia (betis) dan tumit.

Maklumat selanjutnya boleh didapati dalam artikel di Jurnal Nature Genetics (2009)….

Nature Genetics 41, 527 – 534 (2009)
Published online: 26 April 2009 | doi:10.1038/ng.357

A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits

Yoon et al. (2009)


To identify genetic factors influencing quantitative traits of biomedical importance, we conducted a genome-wide association study in 8,842 samples from population-based cohorts recruited in Korea. For height and body mass index, most variants detected overlapped those reported in European samples. For the other traits examined, replication of promising GWAS signals in 7,861 independent Korean samples identified six previously unknown loci. For pulse rate, signals reaching genome-wide significance mapped to chromosomes 1q32 (rs12731740, P = 2.9 times 10-9) and 6q22 (rs12110693, P = 1.6 times 10-9), with the latter approx400 kb from the coding sequence of GJA1. For systolic blood pressure, the most compelling association involved chromosome 12q21 and variants near the ATP2B1 gene (rs17249754, P = 1.3 times 10-7). For waist-hip ratio, variants on chromosome 12q24 (rs2074356, P = 7.8 times 10-12) showed convincing associations, although no regional transcript has strong biological candidacy. Finally, we identified two loci influencing bone mineral density at multiple sites.

On chromosome 7q31, rs7776725 (within the FAM3C gene) was associated with bone density at the radius (P = 1.0 times 10-11), tibia (P = 1.6 times 10-6) and heel (P = 1.9 times 10-10). On chromosome 7p14, rs1721400 (mapping close to SFRP4, a frizzled protein gene) showed consistent associations at the same three sites (P = 2.2 times 10-3, P = 1.4 times 10-7 and P = 6.0 times 10-4, respectively).

This large-scale GWA analysis of well-characterized Korean population-based samples highlights previously unknown biological pathways.


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